Red Cell Rheology

2, 401, 1964 BESSIS, M., MOHANDAS, N.: Deformability of normal, shape-altered and pathological red cells. Blood Cells 1, 315, 1975 BESSIS, M., WEED, R.J., LEBLOND, P.E.: Red Cell Shape. Physiology, Pathology, Ultrastructure.

Red Cell Rheology

Hemolysis during filtration through micropores studied by Chien et al. [I] showed a dependence on pressure gradient and pore diameter that, at the time of publication, did not permit an easy interpretation of the hemolytic mechanism. Acting on the assumption that thresholds of hemolysis are easier to correlate with physical forces than extents of hemolysis, we performed a series of experi ments repeating some of the conditions reported in [I] and then focusing on low L1P in order to define better the thresholds of hemolysis for several pore sizes. Employing a model of a deformed red cell shape at the pore entrance (based on micropipette observations) we related the force field in the fluid to a biaxial tension in the membrane. The threshold for lysis correlated with a membrane tension of 30 dynes/cm. This quantity is in agreement with lysis data from a number of other investigators employing a variety of mechanisms for introduc ing membrane tension. The sequence of events represented here is: a. Fluid forces and pressure gradients deform the cell into a new, elongated shape. b. Extent of deformation becomes limited by the resistance of the cell mem brane to undergo an increase in area. c. Fluid forces and pressure gradients acting on the deformed cell membrane cause an increase in biaxial tension in the membrane. d. When the strain caused by this tension causes pores to open in the membrane, the threshold for hemolysis has been reached [2].

More Books:

Red Cell Rheology
Language: en
Pages: 440
Authors: M. Bessis, S.B. Shohet, N. Mohandas
Categories: Science
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Hemolysis during filtration through micropores studied by Chien et al. [I] showed a dependence on pressure gradient and pore diameter that, at the time of publication, did not permit an easy interpretation of the hemolytic mechanism. Acting on the assumption that thresholds of hemolysis are easier to correlate with physical
Clinical Blood Rheology
Language: en
Pages: 228
Authors: Gordon D.O. Lowe
Categories: Medical
Type: BOOK - Published: 2019-06-04 - Publisher: CRC Press

Published in 1988: Study of blood flow properties (rheology) has attracted growing interest from clinicians in recent years. A United Kingdom meeting and a European meeting in 1979 resulted in previous publications summarizing the literature up to that time.
Handbook of Hemorheology and Hemodynamics
Language: en
Pages: 455
Authors: Oğuz K. Baskurt
Categories: Medical
Type: BOOK - Published: 2007-01-01 - Publisher: IOS Press

Focuses on the macro- and micro-rheological behavior of blood and its formed elements, on interactions between the formed elements and blood vessel walls, and on the microvascular aspects of hemodynamics. This book provides a general overview of both basic science and clinical hemorheology and hemodynamics.
Clinical Blood Rheology
Language: en
Pages: 245
Authors: Gordon D.O. Lowe
Categories: Medical
Type: BOOK - Published: 2019-06-04 - Publisher: CRC Press

Published in 1988: Study of blood flow properties (rheology) has attracted growing interest from clinicians in recent years. A United Kingdom meeting and a European meeting in 1979 resulted in previous publications summarizing the literature up to that time.
Red Cell Rheology (I)
Language: en
Pages: 221
Authors: Stephen B. Shohet
Categories: Blood
Type: BOOK - Published: 1977 - Publisher:

Books about Red Cell Rheology (I)